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href="https://www.nobelprize.org/prizes/chemistry/2021/summary/"> Benjamin List and David W.C. MacMillan win the 2021 nobel prize for their contribution to asymmetric organic catalysis. Back to 2000, Benjamin List propose that one can use only small part of enzyme to do the chemical reaction, he first use L-Prolin, a chiral organic amino acid to specific construct diastereomer. After that, people start to realize that a simple chiral organic molecule can act as catalyst. He bring this general idea to this field. https://www.nobelprize.org/prizes/chemistry/2021/summary/

This paper provide a new synthetic strategy to syntheis indoline derivatives by using commercial available chiral transient amine, gives a good ee( up to 94%) and also shows some potential application to some drug molecules. It provide a practical way to control the intramolecular enantioselective C-H activation. https://pubs.acs.org/doi/10.1021/jacs.9b07251

This new chiral amine has a methoxyl group in the ortho positions, which may contribute some hydrogen bonding to arene ligands.

A new chiral amine has been synthesis for the first time, it has been proved that allow a high enantioselectivity for intramolecular C-H activation for dinapsoline analogys.

This paper report a new synthetic pathway to do directly aromatic hydroxylation using a tautomeric ligand, the substrate scope is broad. https://www.science.org/doi/10.1126/science.abg2362