weinan

It is surprising that none of the 2021 Nobel laureates are women, in fact, there are 96% of nobel winner are men. One might curious the reasons. https://th econversation.com/none-of-the-2021-science-nobel-laureates-are-women-heres-why-men-still-dominate-stem-award-winning-169493

This paper use Rhodium as catalyst with differnet chiral ligands to achieve enantioselective intramolecular C-H activation, the substrate scope is wide. only orthor position has reactivity. https://pubs.acs.org/doi/10.1021/jo801098z

dinapsoline and dinoxyline are drugs moleculars for treatment of Parkinson's disease, the traditional synthetic pathway to those drugs moleculars need more than 10 steps and cannot control the enantioselectivities, in additions, it also involve a lot of toxic chemical. So, here I design a new synthetic pathway that can synthesis the same molecule with fewer steps and up to 84% ee.

https://www.sciencenews.org/article/first-exoplanet-discovery-outside-milky-way-galaxy-astronomy A galaxy was found 28 million light-years away from the Earth, which scientists believe there are plenty of planets in that galaxy may have extraterrestrial life.

When synthesis asymmetry alkene, there is always two different products, one is Cis, one is trans, in general, the trans olefin is always easy to synthesis because the lower energy, here I synthesis a Cis alkene by wittig reaction using Crown ether to chelate with potassium carbonate.

As we all know phosphines are important ligands in organic metalic, one can synthesis different Phosphines ligand to contro the reactivity, e.g, with electron donating group, a Phosphines ligands can enrich the electrodensity in metal center and improve the rate of oxidative addition. in addition, by modify the phosphines ligands, one can control the steric of reaction center, the advantage is not only control the selectivity but also improve the reaction rate for dissociation mechanism. This paper has very comprehensive rewiew on phosphine ligand, including ligands synthesis and application. https://pubs.rsc.org/en/content/chapterhtml/2019/bk9781788014991-00001?isbn=978-1-78801-499-1